## 1 Introduction

### 1.1 Description

Interlog protein network reconstruction by Mapping and Mining ANalysis (IMMAN) is free R/Bioconductor package and Java code script for reconstructing Interlog Protein Network (IPN) . In order to mine the conserved common network among species, users can unify the several (2, 3 and 4) PPINs from various species. IMMAN contains some optional features to retrieve different degrees of conserved IPNs regarding functional genomics and PPIN analysis. Each development has its own help manual and quite straightforward workflow for implementation. To access IMMAN R package, you can refer to Bioconductor . Furthermore, the Java code is available on click here .

### 1.2 How to install

This package can be used in R environment platform. IMMAN is now available on Bioconductor repository. To download it, please click here.

To install it directly from R:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("IMMAN")

### 1.3 How to cite

To dive into the concept of IPN reconstruction and its applications in biological researches , you can access our pervious related publications from the following links:

“Jafari, M., Sadeghi, M., Mirzaie, M., Marashi, S., & Rezaei-Tavirani, M. (2013). Evolutionarily conserved motifs and modules in mitochondrial protein-protein interaction networks. Mitochondrion, 13(6), 668–675. (https://doi.org/10.1016/j.mito.2013.09.006).”"

“Jafari, M., Mirzaie, M., & Sadeghi, M. (2015). Interlog protein network: an evolutionary benchmark of protein interaction networks for the evaluation of clustering algorithms. BMC Bioinformatics, 16(1), 319. (https://doi.org/10.1186/s12859-015-0755-1).”