Systems Biomedicine of Rabies

Rabies is a member of the Rhabdoviridae family that causes lethal encephalitis. The lethality mechanism, as well as related psychological symptoms, have still remained a mystery. The mechanistic view based on signaling networks would be expected to disclose events that occur in the late stage of rabies.

In this project, we undertake a systems biomedicine approach to identify the network of gene products implicated in rabies for predicting potential drug targets. This project is funded by Pasteur Institute of Iran (IPI-748, IPI-888 & IPI-928).

News

Workflow

1. Molecular Interaction Network Reconstruction of Infected Neuro-Host Cell by Rabies Virus

2. Study of Rabies Virus-Rat Brain Tissue Protein-Protein Interactions by Combined Use of 2DE-Far-Western Immunoblotting and Mass Spectrometry

 

3. Apoptosis Induction in Nerve Cells Infected with Rabies Virus based on Boolean Networks Simulation and Protein-Ligand Docking

Partners

Mohieddin Jafari, Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Alireza Gholami, WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran.

Claudine Chaouiya, Instituto Gulbenkian de Ciência, Oeiras Portugal.

Mehdi Mirzaie, Department of Applied Mathematics, Faculty of Mathematical Sciences, Tarbiat Modares University, Tehran, Iran.

Sadegh Azimzadeh Jamalkandi, Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Behrouz Vaziri, Protein Chemistry and Proteomics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Presentations

  • "Systems Biomedicine of Rabies", School of Biological sciences, Institute for research in fundamental sciences (IPM), 9 Feb 2017.